Primary Biliary Cirrhosis

Primary biliary cirrhosis. Detail of portal tract and surrounding parenchyma. This cytokeratin 7 immunostain highlights an increase in the number of ductular structures at the portal tract periphery; expression of cytokeratin 7 in periportal hepatocytes (early stage of cholate stasis), and a few scattered, small cytokeratin 7 positive cells at some distance from the portal tract (presumed hepatic progenitor cells). (Immunostain for cytokeratin 7)